AKC Working Great Pyrenees
Isabelle of Little Deer Creek Farm
Spayed "Aunt" of the farm
Everest of Little Deer Creek Farm
Genetic DNA Wisdom Panel Clear of all 159 tested genetic disease mutations 1/30/20 including Glanzmann's Thrombasthenia and Canine Multifocal Retinopathy. Negative for Neuronal Degeneration (NDG) mutation performed by the University of Minnesota canine lab.
Oscar of Little Deer Creek Farm
Genetic DNA Wisdom Panel Clear of all 210 tested genetic disease mutations 12/30/20 including Glanzmann's Thrombasthenia and Canine Multifocal Retinopathy. Negative for Neuronal Degeneration (NDG) mutation performed by the University of Minnesota canine lab.
Great Pyrenees Breed Tests:
Congenital Cardiac Exam
OFA thyroid evaluation from an approved laboratory
OFA Elbow Dysplasia Evaluation
OFA evaluation based on BAER test
OFA Shoulder OCD Evaluation
ACVO Eye Exam
Canine Multifocal Retinopathy (CMR)
Glanzmann's Thrombasthenia (GT)
Canine Multi-focal Retinopathy (CMR)
Canine Multi-focal Retinopathy (CMR) is a recessively inherited eye disease. Early clinical studies in 1998 by Dr. Bruce Grahn at the University of Saskatchewan, Canada, first described CMR in the Great Pyrenees. The condition observed in each of the named breeds at an ophthalmologistâ€™s exam includes numerous distinct (i.e. multi-focal), roughly circular patches of elevated retina with accumulation of material that produces gray-tan-pink colored lesions. These lesions, looking somewhat like blisters, vary in location and size, although typically they are present in both eyes of the affected dog.Discrete areas of tapetal hyper-
reflectivity might also be seen.
Neuronal Degeneration (NDG)
An inherited neurological disease termed Neuronal Degeneration (NDG), has been reported in Great Pyrenees dogs. The age-of-onset of this disease is very young, well before an affected dogâ€™s first birthday, but begins quite mildly. Initial signs include slipping, sliding, and difficulty maneuvering on smooth surfaces. The gait is abnormal - the dog may seem weak, clumsy, or uncoordinated. Over time, these problems progress and worsen. The abnormalities are most pronounced in the hind limbs, and both sides of the body tend to be affected symmetrically. Eventually, affected dogs display a wide-base stance, become unable to negotiate stairs, have a generalized loss of control and coordination over body movements, and may experience intermittent falling. The condition itself is non-painful, although stumbling and falling can obviously cause pain and traumatic injuries
Degenerative Myelopathy (DM)
Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy, is an incurable, progressive disease of the canine spinal cord that is similar in many ways to amyotrophic lateral sclerosis (ALS). Onset is typically after the age of 7 years and it is seen most frequently in the German shepherd dog, Pembroke Welsh corgi, and boxer dog, though the disorder is strongly associated with a gene mutation in SOD1 that has been found in 43 breeds as of 2008, including the wire fox terrier, Chesapeake Bay retriever, Rhodesian ridgeback, and Cardigan Welsh corgi. Progressive weakness and incoordination of the rear limbs are often the first signs seen in affected dogs, with progression over time to complete paralysis. Myelin is an insulating sheath around neurons in the spinal cord. One proposed cause of degenerative myelopathy is that the immune system attacks this sheath, breaking it down. This results in a loss of communication between nerves in lower body of the animal and the brain.
Glanzmann's Thrombasthenia (GT)
Glanzmann's Thrombasthenia (GT) is a rare bleeding disorder in which the platelets are defective. Platelets have the ability to stick together to stop the flow of blood from injured blood vessels until clotting and tissue repair occurs. While dogs with GT have normal platelet counts, they have abnormal platelet aggregation and blood clotting and thus are at risk of life-threatening bleeding, including spontaneous hemorrhage and excessive hemorrhage as a result of injury or surgery. The disease often manifests itself in young dogs with bleeding gums and/or nosebleeds. GT has been recognized in several breeds, in particular Otter Hounds and Great Pyrenees. GT is an inherited autosomal recessive disorder